In recent years, numerous papers have been published in professional journals and elsewhere evaluating the long-term use and clinical safety of oral creatine monohydrate supplementation using Creapure®.

The main focus was to evaluate if long-term Creapure® supplementation (average of 5 grams/day) might increase the incidence of musculoskeletal injury, heat-related disorders (e.g., dehydration and cramping), and renal stress.

Clinical assessments included analyzing a comprehensive panel of serum and whole blood markers (electrolytes, muscle and liver enzymes, substrates, lipid profiles, red and white blood cells, etc.), renal function tests determined by creatinine clearance, monitoring of injuries treated by the medical/athletic training staff, as well as the collection of medical safety and fatigue/weakness data.

The results of these safety studies on the long-term use of Creapure® have consistently shown that, in comparison to athletes who did not take creatine, those who took creatine did not experience a greater incidence of injuries, heat-related disorders (dehydration), cramping, musculoskeletal injuries, or gastrointestinal disturbances. Additionally, athletes who took creatine over a long period did not have significantly higher muscle and liver enzymes, altered electrolytes, or increased renal stress determined by creatine clearance.